Drug Combination Details
| General Information of the Combination (ID: C67567) | |||||
|---|---|---|---|---|---|
| Name | Thymoquinone NP Info | + | 5-fluorouracil Drug Info | ||
| Structure |
|
+ |
|
||
| Disease |
Stomach cancer
[ICD-11: 2B72]
|
Investigative | [1] | ||
|
Colorectal cancer
[ICD-11: 2B91]
|
Investigative | [2] | |||
| Combinatorial Therapeutic Effect(s) Validated Clinically or Experimentally | ||||||
|---|---|---|---|---|---|---|
| α. Enhancing Drug Efficacy by This Combination | ||||||
| Achieving Therapeutic Synergy | Click to Show/Hide | |||||
| Experiment 1 Reporting the Effect of This Combination | [1] | |||||
| Molecule(s)
Regulation |
Up-regulation | Expression | BAX | Molecule Info |
Pathway MAP
|
|
| Down-regulation | Expression | BCL-2 | Molecule Info |
Pathway MAP
|
||
| Up-regulation | Expression | CASP3 | Molecule Info |
Pathway MAP
|
||
| Up-regulation | Expression | CASP9 | Molecule Info |
Pathway MAP
|
||
| Biological
Regulation |
Up-regulation | Cytochrome c release | ||||
| In-vitro Model | BGC-823 | CVCL_3360 | Gastric cancer | Homo sapiens | ||
| SGC-7901 | CVCL_0520 | Human gastric cancer | Homo sapiens | |||
| MGC-803 | CVCL_5334 | Gastric mucinous adenocarcinoma | Homo sapiens | |||
| HGC-27 | CVCL_1279 | Gastric carcinoma | Homo sapiens | |||
| In-vivo Model | Cells (5*106) resuspended in 0.2 mL PBS were subcutaneously inoculated into the lower right flank of nude mice. | |||||
| Experimental
Result(s) |
Thymoquinone can activate caspase-3 and caspase-9 and thus result in the chemosensitisation of gastric cancer cells to 5-FU-induced cell death. | |||||
| Experiment 2 Reporting the Effect of This Combination | [3] | |||||
| Molecule(s)
Regulation |
Down-regulation | Expression | COX-2 | Molecule Info |
Pathway MAP
|
|
| Down-regulation | Expression | CTNNB1 | Molecule Info |
Pathway MAP
|
||
| Up-regulation | Expression | DKK1 | Molecule Info |
Pathway MAP
|
||
| Up-regulation | Expression | GPX1 | Molecule Info |
Pathway MAP
|
||
| Down-regulation | Expression | NOS2 | Molecule Info |
Pathway MAP
|
||
| Down-regulation | Expression | p105 | Molecule Info |
Pathway MAP
|
||
| Up-regulation | Expression | SMAD4 | Molecule Info |
Pathway MAP
|
||
| Up-regulation | Expression | TGFB1 | Molecule Info |
Pathway MAP
|
||
| Up-regulation | Expression | TGFBR2 | Molecule Info |
Pathway MAP
|
||
| Down-regulation | Expression | VEGFA | Molecule Info |
Pathway MAP
|
||
| Down-regulation | Expression | WNT1 | Molecule Info |
Pathway MAP
|
||
| In-vivo Model | For induction of colorectal tumorigenesis, AOM was dissolved in normal saline and injected subcutaneously at a dose of 15 mg/kg, once weekly for 2 weeks. | |||||
| Experimental
Result(s) |
Thymoquinone subdues tumor growth and potentiates the chemopreventive effect of 5-fluorouracil on the early stages of colorectal carcinogenesis in rats. | |||||
| β. Decreasing Adverse Drug Reaction by This Combination | ||||||
| Decreasing Adverse Drug Reaction | Click to Show/Hide | |||||
| Experiment 1 Reporting the Effect of This Combination | [2] | |||||
| Molecule(s)
Regulation |
Down-regulation | Phosphorylation | AKT1 | Molecule Info |
Pathway MAP
|
|
| Down-regulation | Expression | CTNNB1 | Molecule Info |
Pathway MAP
|
||
| Down-regulation | Phosphorylation | MEK1 | Molecule Info |
Pathway MAP
|
||
| In-vitro Model | HCT 116 | CVCL_0291 | Colon carcinoma | Homo sapiens | ||
| HT29 | CVCL_A8EZ | Colorectal adenocarcinoma | Mus musculus | |||
| Experimental
Result(s) |
Combination of 5-fluorouracil and thymoquinone targets stem cell gene signature in colorectal cancer cells. | |||||
