Drug Combination Details
| General Information of the Combination (ID: C71802) | |||||
|---|---|---|---|---|---|
| Name | Curcumin NP Info | + | Thioridazine Drug Info | ||
| Structure |
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+ |
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| Disease |
Metastatic lymph node neoplasm
[ICD-11: 2D60]
|
Investigative | [1] | ||
|
Breast cancer
[ICD-11: 2C60]
|
Investigative | [1] | |||
|
Brain cancer
[ICD-11: 2A00]
|
Investigative | [1] | |||
| Combinatorial Therapeutic Effect(s) Validated Clinically or Experimentally | ||||||
|---|---|---|---|---|---|---|
| α. Enhancing Drug Efficacy by This Combination | ||||||
| Augmenting Drug Sensitivity | Click to Show/Hide | |||||
| Experiment 1 Reporting the Effect of This Combination | [1] | |||||
| Molecule(s)
Regulation |
Down-regulation | Expression | CFLAR | Molecule Info |
Pathway MAP
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| Up-regulation | Expression | GABPA | Molecule Info | |||
| Down-regulation | Expression | MCL1 | Molecule Info |
Pathway MAP
|
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| Up-regulation | Cleavage | PARP1 | Molecule Info |
Pathway MAP
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| Up-regulation | Cleavage | PARP1 | Molecule Info |
Pathway MAP
|
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| Up-regulation | Expression | PSMA5 | Molecule Info |
Pathway MAP
|
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| Biological
Regulation |
Induction | ROS generation | ||||
| In-vitro Model | AMC-HN-4 | CVCL_5962 | Tongue squamous cell carcinoma | Homo sapiens | ||
| Experimental
Result(s) |
Thioridazine plus curcumin induces proteasome activity by up-regulating PSMA5 expression via NOX4-mediated ROS production and that down-regulation of c-FLIP and Mcl-1 expression post-translationally is involved in apoptosis. | |||||
