Drug Combination Details
| General Information of the Combination (ID: C93800) | |||||
|---|---|---|---|---|---|
| Name | Capsaicin NP Info | + | 3,3'-diindolylmethane Drug Info | ||
| Structure |
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+ |
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| Disease |
Colorectal cancer
[ICD-11: 2B91]
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Investigative | [1] | ||
| Combinatorial Therapeutic Effect(s) Validated Clinically or Experimentally | ||||||
|---|---|---|---|---|---|---|
| α. Enhancing Drug Efficacy by This Combination | ||||||
| Achieving Therapeutic Synergy | Click to Show/Hide | |||||
| Experiment 1 Reporting the Effect of This Combination | [1] | |||||
| Molecule(s)
Regulation |
Up-regulation | Expression | BAK | Molecule Info |
Pathway MAP
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| Up-regulation | Expression | BAX | Molecule Info |
Pathway MAP
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| Up-regulation | Expression | BBC3 | Molecule Info |
Pathway MAP
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| Up-regulation | Expression | BID | Molecule Info |
Pathway MAP
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| Down-regulation | Expression | CDK4 | Molecule Info |
Pathway MAP
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| Down-regulation | Expression | CDK6 | Molecule Info |
Pathway MAP
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| Up-regulation | Expression | CDKN1A | Molecule Info |
Pathway MAP
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| Up-regulation | Expression | FAS | Molecule Info |
Pathway MAP
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| Up-regulation | Expression | IFI27 | Molecule Info | |||
| Up-regulation | Expression | p105 | Molecule Info |
Pathway MAP
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| Up-regulation | Expression | TP53 | Molecule Info |
Pathway MAP
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| In-vitro Model | HCT 116 | CVCL_0291 | Colon carcinoma | Homo sapiens | ||
| SW480 | CVCL_0546 | Colon adenocarcinoma | Homo sapiens | |||
| LoVo | CVCL_0399 | Colon adenocarcinoma | Homo sapiens | |||
| Caco-2 | CVCL_0025 | Colon adenocarcinoma | Homo sapiens | |||
| HT-29 | CVCL_0320 | Colon adenocarcinoma | Homo sapiens | |||
| Experimental
Result(s) |
Capsaicin and DIM work synergistically to inhibit cell proliferation and induce apoptosis in colorectal cancer through modulating transcriptional activity of NF-kappaB, p53, and target genes associated with apoptosis. | |||||
| References | ||||
|---|---|---|---|---|
| Reference 1 | Synergistic anticancer activity of capsaicin and 3,3'-diindolylmethane in human colorectal cancer. J Agric Food Chem. 2015 May 6;63(17):4297-304. | |||
