Drug Details
| General Information of the Drug (ID: DR2520) | ||||
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| Name |
Dextran sulfate sodium
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| Disease | Human immunodeficiency virus disease [ICD-11: 1C62] | Phase 1 | [1] | |
| Combinatorial Therapeutic Effect(s) Validated Clinically or Experimentally | ||||||
|---|---|---|---|---|---|---|
| α. A List of Natural Product(s) Able to Decrease the Adverse Effect of This Drug | ||||||
| Acteoside | Cistanche | Click to Show/Hide the Molecular Data of This NP | ||||
| Decreasing Adverse Drug Reaction | Click to Show/Hide | |||||
| Representative Experiment Reporting the Effect of This Combination | [2] | |||||
| Detail(s) |
Combination Info
click to show the detail info of this combination
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| Molecule(s)
Regulation |
Down-regulation | Expression | CSF2 | Molecule Info |
Pathway MAP
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| Down-regulation | Expression | IFNG | Molecule Info |
Pathway MAP
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| Down-regulation | Expression | IL10 | Molecule Info |
Pathway MAP
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| Down-regulation | Expression | TNF | Molecule Info |
Pathway MAP
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| In-vivo Model | Female Balb/c mice weighing 20-22 g were used in this study. | |||||
| Experimental
Result(s) |
In vivo treatment with the herbal phenylethanoid acteoside ameliorates intestinal inflammation in dextran sulphate sodium-induced colitis. | |||||
| Wogonoside | Scutellaria baicalensis | Click to Show/Hide the Molecular Data of This NP | ||||
| Decreasing Adverse Drug Reaction | Click to Show/Hide | |||||
| Representative Experiment Reporting the Effect of This Combination | [3] | |||||
| Detail(s) |
Combination Info
click to show the detail info of this combination
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| Molecule(s)
Regulation |
Down-regulation | Expression | IL6 | Molecule Info |
Pathway MAP
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| Down-regulation | Expression | NLRP3 | Molecule Info |
Pathway MAP
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| Down-regulation | Expression | NOS2 | Molecule Info |
Pathway MAP
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| Down-regulation | Expression | p105 | Molecule Info |
Pathway MAP
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| In-vitro Model | THP-1 | CVCL_0006 | Childhood acute monocytic leukemia | Homo sapiens | ||
| In-vivo Model | Acute colitis was induced by administration of DSS in drinking water in 35-40 days old female BALB/c mice, weighing 18-22 g, | |||||
| Experimental
Result(s) |
Wogonoside may exert its anti-inflammatory effect via dual inhibition of NF-KappaB and NLRP3 inflammasome, suggesting that wogonoside might be a potential effective drug for inflammatory bowel diseases. | |||||
| Target and Pathway | ||||
|---|---|---|---|---|
| Target(s) | Thymidylate synthase (TYMS) | Molecule Info | [4] | |
