Drug Combination Details
| General Information of the Combination (ID: C67056) | |||||
|---|---|---|---|---|---|
| Name | Epigallocatechin gallate NP Info | + | Vorinostat Drug Info | ||
| Structure |
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+ |
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| Disease |
Melanoma
[ICD-11: 2C30]
|
Investigative | [1] | ||
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Breast cancer
[ICD-11: 2C60]
|
Investigative | [2] | |||
| Combinatorial Therapeutic Effect(s) Validated Clinically or Experimentally | ||||||
|---|---|---|---|---|---|---|
| α. Enhancing Drug Efficacy by This Combination | ||||||
| Augmenting Drug Sensitivity | Click to Show/Hide | |||||
| Experiment 1 Reporting the Effect of This Combination | [1] | |||||
| Molecule(s)
Regulation |
Up-regulation | Expression | BAX | Molecule Info |
Pathway MAP
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| Down-regulation | Expression | BCL-2 | Molecule Info |
Pathway MAP
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| Up-regulation | Activity | CASP3 | Molecule Info |
Pathway MAP
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| Up-regulation | Activity | CASP7 | Molecule Info |
Pathway MAP
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| Up-regulation | Activity | CASP9 | Molecule Info |
Pathway MAP
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| Down-regulation | Expression | CCNA1 | Molecule Info |
Pathway MAP
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| Down-regulation | Expression | CDK2 | Molecule Info |
Pathway MAP
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| Down-regulation | Expression | CDK4 | Molecule Info |
Pathway MAP
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| Up-regulation | Expression | CDKN1A | Molecule Info |
Pathway MAP
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| Down-regulation | Expression | p105 | Molecule Info |
Pathway MAP
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| In-vitro Model | A-375 | CVCL_0132 | Amelanotic melanoma | Homo sapiens | ||
| Hs 294T | CVCL_0331 | Melanoma | Homo sapiens | |||
| G-361 | CVCL_1220 | Melanoma | Homo sapiens | |||
| Experimental
Result(s) |
The combination treatment resulted in significantly greater inhibition of cell proliferation, increased apoptosis, activation of p21, p27 and caspases (3, 7 and 9) and Bax as well as down-regulation of cdk2, cdk4, cyclin A, NF-kappaB protein p65/RelA and Bcl2 protein and transcript. | |||||
| Experiment 2 Reporting the Effect of This Combination | [2] | |||||
| Molecule(s)
Regulation |
Down-regulation | Expression | BIRC3 | Molecule Info |
Pathway MAP
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| Up-regulation | Expression | CASP7 | Molecule Info |
Pathway MAP
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| In-vitro Model | MDA-MB-157 | CVCL_0618 | Breast carcinoma | Homo sapiens | ||
| MDA-MB-231 | CVCL_0062 | Breast adenocarcinoma | Homo sapiens | |||
| MCF-7 | CVCL_0031 | Invasive breast carcinoma | Homo sapiens | |||
| Experimental
Result(s) |
SAHA and EGCG promote apoptosis in triple-negative breast cancer cells, possibly through the modulation of cIAP2. | |||||
